Studies on uroporphyrinogen biosynthesis in pig liver.

Assignment of the ovine uroporphyrinogen decarboxylase (UROD) gene to chromosome 1p34 --> p36 by fluorescence in situ hybridization.

Heme biosynthesis is a complex multistep process, taking place partly in the cytosol and partly in the mitochondria. A dysfunction of one or more enzymes in the biochemical pathway results in the accumulation of intermediates of the porphyrin synthesis and to the onset of porphyrias. Porphyrias are mainly hereditary; however, they can also be induced by exogenous factors. Depending on which enz...

Onion, a Potent Inhibitor of Xantine Oxidase

Onion (Allium Cepa) contains high levels of flavonoids. Although there are many studies indicating the inhibitory effects of flavonoids on xanthine oxidase, there is no report on the effect of onion on this enzyme. Therefore, in the present study, the inhibitory effects of onion on xanthine oxidase are investigated. Fresh filtered juice of onion was prepared and its inhibitory effect on guine...

Onion, a Potent Inhibitor of Xantine Oxidase

Onion (Allium Cepa) contains high levels of flavonoids. Although there are many studies indicating the inhibitory effects of flavonoids on xanthine oxidase, there is no report on the effect of onion on this enzyme. Therefore, in the present study, the inhibitory effects of onion on xanthine oxidase are investigated. Fresh filtered juice of onion was prepared and its inhibitory effect on guine...

Effects of Anatoxin B1 on Liver Nuclear DNA Biosynthesis in Growing and Day-old Chickens

Toxicity of polychlorinated biphenyl with special reference to porphyrin metabolism.

Oral administration of a commercial PCB mixture to chickens caused a hepatic-type porphyria characterized by hepatic accumulation and urinary excretion of uroporphyrin. To clarify the mechanism of the porphyrinogenic activity of these PCBs, we studied the structural requirement of synthetic PCB for porphyrinogenic activities by using the cultured chick embryo liver cells and examined the relati...